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KMID : 0665220120250010099
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Korean Journal of Food and Nutrition
2012 Volume.25 No. 1 p.99 ~ p.104
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Ameliorative Effect of Black Ginseng on Diabetic Complications in C57BLKS/J-db/db Mice
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Kim Ae-Jung
Yoo Hyun-Sook
Kang Shin-Jyung
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Abstract
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The goal of this study was to examine the ameliorative effects of black ginseng(BG) in male obese diabetic C57BLKS/ J-db/db mice. Ten-week-old male db/db mice were administrated 300 ㎎/㎏ of F-BG daily for 6 weeks, The db/db mice where corresponded to the normal group and db/db mice which were the diabetic positive group were not provided BG treatment. The supressive effects of treatment were examined on serum lipids levels, which included total cholesterol, triglyceride, LDL-cholesterol and nonesterified fatty acid. Also, weight changes and the relative weight of liver and kidney, organ pathological investigation were measured. The effects of treatment were assessed by comparing the results of the db/db mice that received BG for 6 weeks with that of the diabetic positive group. Significant differences in several biological parameters such as HDL level(p<0.05), TG level(p<0.05) and NEFA level(p<0.05) were observed for the BG group. BG treatment increased the HDL level and decreased the NEFA level, which could ameliorate hyperlipidemia or blood circulation.
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KEYWORD
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C57BLKS/J-db/db mice, black ginseng, serum lipids, liver, kidney
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